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Curriculum Vitae

Update: 2022-10

Basic Information

  • Name: To Sing Fung (Martin)
  • Nationality: China (Hong Kong)

Work Experience

  • Research Associate
    2022.1 – Now
    Department of Infectious Diseases and Public Health
    City University of Hong Kong
    Hong Kong, China

  • Research Associate Professor
    2017.6 – 2021.6
    Integrated Microbiology Research Center
    South China Agricultural University
    Guangzhou, China

  • Post-doctoral Fellow
    2016.3 – 2017.3
    Faculty of Health Sciences
    University of Macau
    Macau, China

  • Post-doctoral Fellow
    2015.1 – 2015.12
    School of Biological Sciences
    Nanyang Technological University
    Singapore

Education

  • Doctor of Philosophy (PhD)
    2011.1 – 2015.1
    School of Biological Sciences
    Nanyang Technological University
    Singapore (Download PhD Thesis)

  • Bachelor of Science (1st Honour)
    2005.9 – 2009.6
    Department of Biochemistry
    Chinese University of Hong Kong
    Hong Kong, China

  • Summer Exchange Student
    2008.5 – 2008.9
    Division of Biology
    California Institute of Technology
    Pasadena CA, US

  • Summer Exchange Student
    2007.5 – 2007.9
    Surface Western
    University of Western Ontario
    London, Canada

Language Proficiency

  • Fluent English
    TOEFL: 115 / 120
    IELTS: 8 / 9
  • Native Cantonese
  • Fluent Mandarin

IT proficiency

  • Experienced user of MSOffice, Adobe Illustrator, Photoshop and Dreamweaver
  • Advanced user of Prism, ImageJ, Snapgene and other biological software
  • Intermediate static web design (HTML5/CSS3)
  • Basic Python and BioPython

Teaching Experience

  • Supervised and co-supervised more than 40 BSc, MSc and PhD students
  • Lecturer of graduate course Molecular Virology (English) for 3 years
  • More than 1000 hours as Teaching Assistant during PhD/Post-doc

Research Focuses

  • Antivirals against coronaviruses infections
  • Plasmonic Photothermal PCR for rapid diagnostics
  • Coronavirus viroporins (Ion channel proteins)
  • Coronavirus-host interactions
  • Reverse genetics of coronavirus and other viruses

Research Grant

Total research grant acquired
as Principal Investigator : ¥1,590,000

  1. Natural Science Foundation of China, Functional study of lysosomal stress activated by coronavirus infection and how it regulates viral replication and pathogenesis, 32170152, 2022-2025, Principal Investigator, ¥580,000;

  2. Natural Science Foundation of China, Functional characterization of infectious bronchitis coronavirus E protein ion channel activity in modulating viral replication and virus-host interaction, 31900135, 2020-2022, Principal Investigator, ¥240,000;

  3. Natural Science Foundation of China, Molecular studies of strategies and mechanisms exploited by coronavirus to regulate cell cycle and optimize cellular microenvironment for efficient replication, 31972660, 2020-2023, participant, ¥590,000;

  4. Natural Science Foundation of Guangdong Province, Characterization of coronavirus envelope protein ion channel activity in modulating viral pathogenesis and virus-host interaction, 2018A030313472, 2018-2021, Principal Investigator, ¥100,000;

  5. Zhaoqing Institute of Biotechnology Co. Ltd, Construction of recombinant infectious bronchitis virus for vaccine development, 2018-2020, participant, ¥450,000;

  6. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Activation of ER stress response and innate immunity during coronavirus infection, MSDC-2017-06, 2017-2020, Principal Investigator, ¥80,000;

  7. Integrate Microbiology Research Center, Internal grant, Principal Investigator:
    2020-2021, ¥200,000
    2019-2020, ¥180,000
    2018-2019, ¥10,000
    2017-2018, ¥200,000

Research Paper

PubMed / Google Scholar
As first/co-first author: 15
As corresponding author: 7
Impact factor > 15 : 3
Impact factor > 5 : 18
Total citation: 2938
H-index: 21
(as of 2022-10)

  1. Yuan LX, Yang B, Fung TS, Chen RA, Liu DX. Transcriptomic analysis reveals crucial regulatory roles of immediate-early response genes and related signaling pathways in coronavirus infectious bronchitis virus infection. Virology. 2022;14(575):1-9. (PDF) IF:3.513

  2. Yuan LX, Fung TS, He JW, Chen RA, Liu DX. Modulation of viral replication, apoptosis and antiviral response by induction and mutual regulation of EGR and AP-1 family genes during coronavirus infection. Emerging Microbes & Infections. 2022;11(1):1717-1729. (PDF) IF:19.568

  3. Li S, Liu S, Chen RA, Huang M, Fung TS*, Liu DX*. Activation of the MKK3­-p38-MK2-ZFP36 axis by coronavirus infection restricts the upregulation of AU-rich element-containing transcripts in proinflammatory response. Journal of Virology. 2022;96(5):e0208621. [* Co-corresponding authors] (PDF) IF:6.549

  4. Zhu QC, Li S, Yuan LX, Chen RA, Liu DX, Fung TS. Induction of the proinflammatory chemokine interleukin-8 Is regulated by integrated stress response and AP-1 family proteins activated during coronavirus Infection. International Journal of Molecular Sciences. 2021;22(11):5646. (PDF) IF:6.208

  5. Fung TS, Liu DX. Similarities and dissimilarities of covid-19 and other coronavirus diseases. Annual Review of Microbiology. 2021;75:19-47. (PDF) IF:16.232

  6. Yuan LX, Liang JQ, Zhu QC, Dai G, Li S, Fung TS*, Liu DX*. gammacoronavirus avian infectious bronchitis virus and alphacoronavirus porcine epidemic diarrhea virus exploit a cell-survival strategy via upregulation of cFOS to promote viral replication. Journal of Virology. 2020;95(4):e02107-20. [* Co-corresponding authors] (PDF) IF:6.549

  7. Dai G, Huang M, Fung TS*, Liu DX*. Research progress in the development of porcine reproductive and respiratory syndrome virus as a viral vector for foreign gene expression and delivery. Expert Review of Vaccines. 2020;19(11):1041-1051. [* Co-corresponding authors] (PDF) IF:5.683

  8. Wang N, Huang M, Fung TS, Luo Q, Ye JX, Du QR, Wen LH, Liu DX, Chen RA. Rapid development of an effective newcastle disease virus vaccine candidate by attenuation of a genotype VII velogenic isolate using a simple infectious cloning system. Frontiers in Veterinary Science. 2020;7:648. (PDF) IF:3.471

  9. Liang XY, Zhu QC, Liang JQ, Liu SY, Liu DX, Fung TS. Development of HiBiT-tagged recombinant infectious bronchitis coronavirus for efficient in vitro and in vivo viral quantification. Frontiers in Microbiology. 2020;11:2100. (PDF) IF:6.064

  10. Li S, Yuan L, Dai G, Chen RA, Liu DX, Fung TS. Regulation of the ER stress response by the ion channel activity of the infectious bronchitis coronavirus envelope protein modulates virion release, apoptosis, viral fitness, and pathogenesis. Frontiers in Microbiology. 2020;10:3022. (PDF) IF:6.064

  11. Fung TS, Liu DX. Human coronavirus: host-pathogen interaction. Annual Review of Microbiology. 2019;73:529-557. (PDF) IF:16.232

  12. Fung TS, Liu DX. The ER stress sensor IRE1 and MAP kinase ERK modulate autophagy induction in cells infected with coronavirus infectious bronchitis virus. Virology. 2019;533:34-44. (PDF) IF:3.513

  13. Liang JQ, Fang S, Yuan Q, Huang M, Chen RA, Fung TS*, Liu DX*. N-Linked glycosylation of the membrane protein ectodomain regulates infectious bronchitis virus-induced ER stress response, apoptosis and pathogenesis. Virology. 2019;531:48-56. [* Co-corresponding authors] (PDF) IF:3.513

  14. Regmi S, Fung TS, Lim S, Luo KQ. Fluidic shear stress increases the anti- cancer effects of ROS-generating drugs in circulating tumor cells. Breast Cancer Research and Treatment. 2018;172(2):297-312. (PDF) IF:4.624

  15. Fung TS, Liu DX. Post-translational modifications of coronavirus proteins: roles and function. Future Virology. 2018;13(6):405-430. (PDF) IF:3.015

  16. Wong HH#, Fung TS#, Fang S, Huang M, Le MT, Liu DX. Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3. Virology. 2018;515:165-175. [# Co-first authors] (PDF) IF:3.513

  17. Fung TS, Liu DX. Activation of the c-Jun NH2-terminal kinase pathway by coronavirus infectious bronchitis virus promotes apoptosis independently of c-Jun. Cell Death & Disease. 2017;8(12):3215. (PDF) IF:9.705

  18. Tan YW#, Fung TS#, Shen H, Huang M, Liu DX. Coronavirus infectious bronchitis virus non-structural proteins 8 and 12 form stable complex independent of the non-translated regions of viral RNA and other viral proteins. Virology. 2018;513:75-84. [# Co-first authors] (PDF) IF:3.513

  19. Zheng J#, Yamada Y#, Fung TS#, Huang M, Chia R, Liu DX. Identification of N-linked glycosylation sites in the spike protein and their functional impact on the replication and infectivity of coronavirus infectious bronchitis virus in cell culture. Virology. 2018;513:65-74. [# Co-first authors] (PDF) IF:3.513

  20. To J#, Surya W#, Fung TS#, Li Y, Verdià-Bàguena C, Queralt-Martin M, Aguilella VM, Liu DX, Torres J. Channel-inactivating mutations and their revertant mutants in the envelope protein of infectious bronchitis virus. Journal of Virology. 2017;91(5):e02158-16. [# Co-first authors] (PDF) IF:6.549

  21. Fung TS, Liao Y, Liu DX. Regulation of stress responses and translational control by coronavirus. Viruses-Basel. 2016;8(7):184. (PDF) IF:5.818

  22. Fung TS, Torres J, Liu DX. The emerging roles of viroporins in er stress response and autophagy induction during virus infection. Viruses-Basel. 2015;7(6):2834-57. (PDF) IF:5.818

  23. Ao D, Guo HC, Sun SQ, Sun DH, Fung TS, Wei YQ, Han SC, Yao XP, Cao SZ, Liu DX, Liu XT. Viroporin activity of the foot-and-mouth disease virus non- structural 2B protein. PLoS One. 2015;10(5):e0125828. (PDF) IF:3.752

  24. Fung TS, Huang M, Liu DX. Coronavirus-induced ER stress response and its involvement in regulation of coronavirus-host interactions. Virus Research. 2014;194:110-23. (PDF) IF:6.286

  25. Fung TS, Liao Y, Liu DX. The endoplasmic reticulum stress sensor IRE1 protects cells from apoptosis induced by the coronavirus infectious bronchitis virus. Journal of Virology. 2014;88(21):12752-64. (PDF) IF:6.549

  26. Liu DX, Fung TS, Chong KK, Shukla A, Hilgenfeld R. Accessory proteins of SARS-CoV and other coronaviruses. Antiviral Research. 2014;109:97-109. (PDF) IF:10.103

  27. Fung TS, Liu DX. Coronavirus infection, ER stress, apoptosis and innate immunity. Frontiers in Microbiology. 2014;5:296. (PDF) IF:6.064

  28. Liao Y#, Fung TS#, Huang M, Fang SG, Zhong Y, Liu DX. Upregulation of CHOP/GADD153 during coronavirus infectious bronchitis virus infection modulates apoptosis by restricting activation of the extracellular signal-regulated kinase pathway. Journal of Virology. 2013;87(14):8124-34. [# Co-first authors] (PDF) IF:6.549

Book Chapter

  1. Liu DX, Ng YL, Fung TS, “Coronaviruses as Vaccine Vector for Veterinary Pathogens”. In Viral Vectors in Veterinary Vaccine Development – A Textbook (pp. 149-168). 2021. Switzerland: Springer International Publishing AG. (PDF)

  2. Liu DX, Liang JQ, Fung TS, “HCoV-229E, -NL63, -OC43, and -HKU1” In Encyclopedia of Virology 4th edition. 2020. US: Elsevier Inc. (PDF)

  3. Liu DX, Ng YL, Fung TS, “Infectious Bronchitis Virus”. In Avian Virology: Current Research and Future Trends (pp. 129-174). 2019. UK: Caister Academic. (PDF)

Conference

  1. (Speaker) Fung TS and Liu DX. Ion channel activity of coronavirus envelope protein regulates viral replication and pathogenesis. Frontiers in Microbiology International Symposium. 2018. Guangzhou, China.

  2. (Speaker) Fung TS. Activation of JNK pathway by coronavirus infectious bronchitis virus promotes apoptosis. 1st National Conference of Signal Communication and Pathogenesis in Microbes. 2017. Guangzhou, China.

  3. (Poster) Fung TS and Luo Q. Studying important human disease using fluorescence-based biosensors. 12th “five-years” Science and Technology Innovation Exhibition. 2016. Macau, China.

  4. (Speaker) Fung TS, Liao Y, Huang M, Liu DX. The ER stress sensor IRE1 protects cells from apoptosis induced by coronavirus infectious bronchitis virus. XIIIth International Nidovirus Symposium. 2014, Salamanca, Spain.

Pattern

  1. 中国发明专利；利用K1E噬菌体RNA聚合酶和启动子的双质粒系统在真核细胞表达病毒蛋白的方法；冯涛声, 刘定祥, 李淑敏, 丘祖纯；申请号：202011145191.2

  2. 中国发明专利；猪繁殖与呼吸综合征病毒重组疫苗株PRRSV-SP及其制备方法与应用；刘定祥, 黄梅, 冯涛声, 代过；申请号：201911119406.0

  3. 中国发明专利；一株S蛋白融合HiBiT的传染性支气管炎重组病毒及制备方法与应用；冯涛声, 刘定祥, 朱庆春, 梁佳琪, 梁潇颖；申请号：201910910558.6

  4. 中国发明专利；一株缺失E蛋白离子通道活性的传染性支气管炎重组病毒及制备方法与应用；冯涛声, 刘定祥, 陈瑞爱, 李淑敏, 李延鹏, 梁佳琪, 袁丽霞, 朱庆春, 罗琼, 熊廷；授权公告日：2022年3月22日；专利号：ZL 2018 1 1449640.5

  5. 中国发明专利；一株M蛋白糖基化位点突变的传染性支气管炎病毒及其制备方法与应用；刘定祥, 冯涛声, 陈瑞爱, 梁佳琪, 李延鹏, 李淑敏, 袁丽霞, 朱庆春, 罗琼, 熊廷；申请号：201811389187.3

Award & Honor

  • Nanyang Technological University
    • Full-Tuition Scholarship (4 years)
    • Overseas Travel Grant
  • Chinese University of Hong Kong
    • Full-Tuition Scholarship (4 years)
    • Faculty of Science Dean’s List (4 years)
    • Sir Edward Youde Memorial Scholarship
    • Caltech-HK Undergraduate Fellowship
    • HSBC Hong Kong Scholarship
    • Bank of East Asia Scholarship
  • CUHK - United College
    • Ming De Scholarship (2009)
    • College Head’s List (2006, 2007, 2009)
    • Ms Wendy Fung Scholarship
    • Tsang Shiu Tim Scholarship
    • Mr & Mrs KL Wong Scholarship
    • Fung Ping Fan Memorial Scholarship
  • CUHK - Department of Biochemistry
    • Prof. Ma Lin’s Acamedic Award
    • Prof. C.Y. Lee Academic Award
    • DREAM program Scholarship
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